New research supports the long-term safety and efficacy of biliopancreatic diversion (BPD) with or without duodenal switch (BPD/DS).
These two weight loss surgery variations are highly complex and drastic procedures that involve bypassing a large portion of the small intestine to limit food absorption. They are generally appropriate options only for patients with a very high body mass index (BMI of 50 or greater).
The study found that overall patients experienced high levels of excess weight loss and while nutritional deficiencies and postoperative complications were high, patients were satisfied with their choice of surgery.
About the Study
The study was conducted by researchers at the New York University School of Medicine in order to learn more about the long-term outcomes after BPD and BPD/DS.
The researchers reviewed the records of patients who underwent these procedures between 1999 to 2011, focusing on weight loss measures at 2, 5, and 10-15 years postoperatively, comorbidity remission, long-term complications, nutritional deficiencies, and patient satisfaction.
The results included 100 patients who underwent BPD (34%) or BPD/DS (64%). The mean preoperative BMI of these patients was 50. Follow-up ranged from 1-15 years, with 72% of eligible patients in active follow-up at 10-15 years postoperatively.
- Excess weight loss (EWL) was 65.1% at 2 years, 63.8% at 5 years, and 67.9% at 10-15 years
- Approximately 10% higher %EWL achieved by patients with lower preoperative BMI (less than 50 vs greater than 50) and in patients who underwent BPD/DS vs BPD
- Comorbidities improved, but 37% of patients developed long-term complications requiring surgery
- No 30-day mortalities; one mortality from severe malnutrition
- Common outcomes were nutritional deficiencies in fat-soluble vitamins, anemia, and secondary hyperparathyroidism
- 94% of patients reported satisfaction with their choice of surgery
Based on study results, BPD and BPD/DS appears to be a safe and effective weight loss option for appropriately selected patients with a high rate of patient satisfaction.
Learn more about Duodenal Switch weight loss surgery.
Monica Sethi, MD, Edward Chau, MD, Allison Youn, MA, Yan Jiang, BS, George Fielding, MD, Christine Ren-Fielding, MD, “Long-Term Outcomes After Biliopancreatic Diversion With and Without Duodenal Switch: 2, 5, and 10-Year Data,” Surgery for Obesity and Related Diseases, published online March 09, 2016; DOI: http://dx.doi.org/10.1016/j.soard.2016.03.006/abstract.